Contains a central nucleotide-binding (NB) subdomain as part of a larger entity called the NB-ARC domain. C-terminal to the NB-ARC domain lies a leucine-rich repeat (LRR) domain, which is sometimes followed by an extension of variable length. Hence, this group of R proteins is collectively referred to as NB-LRR proteins. If N-terminal region shows homology to the protein domain Interleukin-1 Receptor (IL-1R), called the TIR domain, these proteins are referred to as TIR-NB-LRR or TNL.

List of Genes from TNL class

PRGdb IDGene nameTypeSpecies
PRGDB131Bs4referenceSolanum lycopersicum (Pythozome V13)
PRGDB139Gro1.4referenceSolanum tuberosum (Pythozome V13)
PRGDB144NreferenceNicotiana glutinosa
PRGDB152RY-1referenceSolanum tuberosum (Pythozome V13)
PRGDB1486L6referenceLinum usitatissimum (Pythozome V13)
PRGDB1487MreferenceLinum usitatissimum (Pythozome V13)
PRGDB1493RPP5referenceArabidopsis thaliana (Pythozome V13)
PRGDB1496Rps4referenceArabidopsis thaliana (Pythozome V13)
PRGDB135724P2referenceLinum usitatissimum (Pythozome V13)
PRGDB150959RPP1referenceArabidopsis thaliana (Pythozome V13)